Venetoclax is a prescription medication. It’s approved by the Food and Drug Administration for the treatment of newly diagnosed acute myeloid leukemia (AML) in certain adults. Acute myeloid leukemia is a type of cancer that affects your blood cells.Venetoclax specifically is a type of targeted therapy for Acute myeloid leukemia (AML). It works by targeting and inhibiting the action of a specific protein within leukemia cells. Here are some basics facts about Venetoclax:
- Brand-name: Venclexta
- Drug class: BCL-2 inhibitor
- Dosage Form & Strength: 10mg, 50mg and 100mg
- Generic: not approved
Keep reading for more information about Venetoclax and its uses. You can also refer to the article: Venetoclax for Treating Chronic Lymphocytic Leukemia (CLL) for a comprehensive look at its other uses.
About Venetoclax
Venetoclax is a precision cancer medication designed to selectively bind and block the B-cell lymphoma-2 (BCL-2) protein. In some blood cancers B-cell lymphoma-2 builds up and prevents cancerous cells either from dying or self-destructing, a process named apoptosis. Venetoclax inhibits the B-cell lymphoma-2 protein and acts to restore the process of apoptosis.
How well Venetoclax works
Clinical findings demonstrated that the venetoclax tablet is an effective oral treatment for newly diagnosed acute myeloid leukemia (AML) in certain adults.In case you’ve recently been diagnosed with acute myeloid leukemia, it’s quite common to have several questions about how well Venetoclax works. These may include: “Can Venetoclax cure AML?” You may also wonder how long medicines used with Venetoclax work for acute myeloid leukemia (AML). In many cases, it’s possible that Venetoclax can allow your acute myeloid leukemia to go into complete remission after initial treatment. (Complete remission is when signs or symptoms of acute myeloid leukemia have disappeared.) But that doesn’t mean you’re cured with AML. A cure is when the traces of cancer disappear after receiving treatment, and the disease won’t come back. acute myeloid leukemia may not go away completely, and it may come back after a period of remission.
Venetoclax is used with chemotherapy drugs, specifically either:
- cytarabine or
- azacitidine (Onureg, Vidaza) or
- decitabine (Dacogen)
How long these medicines are effective for leukemia treatment (such as for acute myeloid leukemia) can vary. As long as treatment works effectively and safely for you, your health specialist may recommend taking these drugs for a longer time-span.
Dosage and Administration
Venetoclax is approved by the FDA for the treatment of newly diagnosed acute myeloid leukemia (AML). It is approved for use in adult patients aged 75 years or older and in adults who can’t receive standard chemotherapy. Venetoclax is supplied as oral tablets in different dosage strengths. In order to treat acute myeloid leukemia, your Venetoclax dosage will likely be enhanced over the initial 3 to 4 days of therapy. The dosage that you’ll continue to take will typically depend on which medicine your health specialist prescribes with Venetoclax.
Here’s the proposed dosage schedule for Venetoclax for acute myeloid leukemia (AML):
- day 1: venetoclax 100 milligrams (mg)
- day 2: venetoclax 200 mg
- day 3: venetoclax 400 mg
- day 4 and on with azacitidine or decitabine: venetoclax 400 mg
- day 4 and on with cytarabine:
venetoclax 600 mgProposed dosage of Venetoclax need to be taken daily on a regular basis for as long as a healthcare professional recommends. Venetoclax tablets need to be swallowed whole with a drink of water. Make sure to take your daily dosage with a meal. Venetoclax is likely to be taken once daily. Treatment is meant for long-term use.
Note: In addition to treating acute myeloid leukemia, the drug venetoclax 100 mg tablet has certain other uses. Please Keep in mind that the medicine’s dosing may differ for these other uses. In order to learn more, talk to your health specialist.
About Acute Myeloid Leukemia (AML) Each year in the US, acute myeloid leukemia is diagnosed in around 20,000 individuals. It is an aggressive leukemia, having lowest survival rates (SR) of any acute leukemias. Acute myeloid leukemia prevents certain immune cells from forming properly, leaving them in immature stages. These cancerous or malignant cells, referred to as blasts, are not capable of fighting infection as intended, and quickly accumulate in the body. This crowds out other blood cells so that they are not capable of carrying out their crucial functions.With currently existing therapies around 27 % of patients diagnosed with acute myeloid leukemia will survive 5 years or more. The disease recurrence emerges in most patients within the 3 years of diagnosis. Older individuals diagnosed with acute myeloid leukemia fare worse and only around one-third of those older than aged 60 are capable in order to tolerate the intensive chemotherapy needed to achieve the optimal outcomes.
Symptoms of AML: The symptoms of AML emerge when the body can’t precisely develop healthy blood cells (such as RBCs, WBCs, and platelets.In absence of enough healthy blood cells, the common symptoms of acute myeloid leukemia can include:
- fever
- feeling tired
- bruising easily
- bleeding more than usual
Side Effects Due to Venetoclax
Use of Venetoclax for acute myeloid leukemia (AML) may be responsible for causing side effects that are minimal or severe. The below mentioned list include some of the major side effects that have been reported in individuals taking Venetoclax.
Note: For information about other potential side effects of the medicine, talk with your health specialist.
Mild side effects: Like other medicinal products, Venetoclax can cause certain minimal side effects. These venetoclax side effects may be temporary, lasting some days or weeks. But in case they are persistent, or in case they bother you or become severe, it’s crucial to discuss with your health specialist.
Common mild side effects due to Venetoclax for acute myeloid leukemia may include:
- rash
- nausea
- vomiting
- diarrhea
- edema
- fever
- belly pain
- dizziness
- cough
- sore throat
- constipation
- lack of energy
- pain in the muscles, joints, or bones
Severe side effects: Severe side effects are possible due to treatment with Venetoclax. Call your health specialist promptly in case of occurrence of severe side effects while taking Venetoclax.
Severe but less common side effects due to Venetoclax may include:
- severe blood disorders, such as neutropenia (reduced WBC count), anemia (reduced RBC count), or thrombocytopenia (reduced platelet count)
- tumor lysis syndrome (a condition in which cancerous cells release hazardous chemicals into the blood)
- severe infections, such as pneumonia (lung infection) or sepsis (blood infection)allergic reactions.
Cost of Venetoclax
How much venetoclax costs is based on different factors. These can include the patient's prescribed treatment regimen, the insurance plan, the pharmacy, and patient's location. For estimates of how much venetoclax costs, see https://www.indianpharmanetwork.in. Venetoclax (Brand-Name: Venclexta/Venclyxto) typically is a prescription medication. It’s not currently authorized in a generic form. The brand-name medicines usually cost more than their generic alternatives. If you are looking to buy Venetoclax in India online at the most authentic and lowest prices, then connect to us at TOLL-FREE: 1800-889-1064, or you can tell us about your requirement via E-mail: info@indianpharmanetwork.in. Indian Pharma Network is your one-stop solution and a legitimate Supplier, Exporter, Retailer and Wholesaler of Generic and Branded prescription drugs. To get the most promising venetoclax price in India, contact us today.
